应用直接酶标法对来自全国17个地区的2346份肝组织标本进行了肝内HDAg的检测,1764份HBsAg阳性标本中有167份检出HDAg,检出率为9.47％。各大地区HDAg检出率无显著性差异。肝内HDAg的检出率与病理类型有关,慢性肝病和重症肝炎中HDAg检出率较高。提示:HDV感染与疾病的活动性及慢性化有关。对HDV与HBV复制关系的研究表明:HDV可以抑制HBV的复制,但两者也可同时复制,其机理尚不清楚。 The intrahepatic HDAg was detected in 2346 liver tissue samples from 17 regions of China by direct enzyme labeling method. Of the 1764 HBsAg positive samples, 167 were detected HDAg, the detection rate was 9.47%. There was no significant difference in the detection rate of HDAg in various regions. The detection rate of intrahepatic HDAg is related to the pathological type, and the detection rate of HDAg in chronic liver disease and severe hepatitis is higher. Hint: HDV infection is related to disease activity and chronicity. The study on the relationship between HDV and HBV replication shows that HDV can inhibit the replication of HBV, but the two can also replicate at the same time. The mechanism is not clear.