在日本肺癌死亡率呈显著上升趋势，尤其是已成为男性发病率最高的癌症。吸烟是肺癌最重要的环境因子，但据认为个体的易感性是由宿主的基因与环境因子相互作用所决定的。香烟中存在的ｂｅｎｚｏ（ａ）ｐｙｒｅｎｅ等诱发癌症物质在药物代谢的第一相反应中被活化，在接着发... The mortality rate of lung cancer in Japan has shown a significant upward trend, and in particular it has become the highest incidence of cancer in men. Smoking is the most important environmental factor for lung cancer, but it is believed that the individual’s susceptibility is determined by the interaction of the host’s genes with environmental factors. The benzo(a)pyrene and other cancer-inducing substances present in cigarettes are activated in the first-phase reaction of drug metabolism.