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胃动素(motilin)是由22个氨基酸残基组成的多肽,最初由猪的十二指肠和空肠粘膜中分离出来,它对胃肠道平滑肌具有广泛的影响。近年来发现,在中枢神经系统内的垂体、松果体、下丘脑、纹状体以及脑皮质等部位均含有胃动素,它在CNS内的生理作用尚不清楚。本文作者Porreca等向大鼠的侧脑室和蛛网膜下腔注射一定量的胃动素,观察了对膀胱收缩功能的影响。实验选用体重200～220g、麻醉的雌性大鼠,维持正常体温,用生理盐水缓慢充盈膀胱,直到出现膀胱收缩反射,在恒定的膀胱容量情况下,记录自发的膀胱收缩曲线,以抑制排尿的时间,作为测定药物效应指标。
Motilin is a polypeptide of 22 amino acid residues originally isolated from porcine duodenum and jejunal mucosa and has a wide range of effects on gastrointestinal smooth muscle. In recent years, it has been found that motilin is contained in the pituitary, pineal, hypothalamus, striatum and cerebral cortex in the central nervous system, and its physiological role in the CNS is unclear. Porreca et al. Injected a certain amount of motilin into the lateral ventricle and subarachnoid space of rats to observe the effect on bladder contractile function. The experiment selected the weight of 200 ~ 220g, anesthetized female rats to maintain normal body temperature, slowly filling the bladder with normal saline until bladder contractile reflex, in the case of constant bladder capacity, spontaneous bladder contraction curve recorded in order to inhibit urination time , As a measure of drug effect indicators.