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目的：了解近年来尿路感染患者病原菌分布及变化趋势，为临床合理使用抗生素提供理论依据。方法收集2010年8月至2013年12月我院住院的尿路感染患者尿液标本中分离的病原菌182株，对其进行鉴定及药敏分析。结果所有分离的病原菌中，大肠埃希菌107例，占58.8%，大肠杆菌对碳青霉烯类药物敏感率为100%。革兰阳性球菌对青霉素耐药率高达90%，对万古霉素敏感率为100%。结论目前尿路感染病原菌仍以大肠埃希菌为主，病原菌对不同抗生素的耐药率均有上升，临床医师应参考当地药敏结果合理选用抗生素。“,”Objective To analyze the distribution of pathogens in urinary tract infection and the trends of drug resistance, in order to provide theoretical support for rational use of antibiotics.Methods 182 strains of pathogens from patients with urinary tract infection from August 2010 to December 2013 were colected and cultivated.Results In 182 positive strains, 107 were bacili (58.8%), which were al sensitive to Carbapenems. The resistance rate of gram-positive bacili to penicilin and vancomycin were 90% and 0.0%.Conclusion The gram-negative bacili remain the predominant pathogens causing urinary tract infection. Resistance rates among common pathogens appear to be increasing to many common used agents. Drug-sensitivity tests are needed in treatment of urinary tract infection.