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目的:探讨乙型肝炎病毒感染妊娠期肝内胆汁淤积症(ICP)孕妇母儿免疫系统影响及妊娠结局分析。方法:回顾性分析2009年1月~2014年1月来该院妇科就诊的267例妊娠期肝内胆汁淤积症孕妇,其中合并乙型肝炎病毒(HBV)感染97例为观察组,无HBV感染170例为对照组。对两组孕妇免疫功能指标(IL-18、IL-12、TNF-α)和妊娠结局进行对比研究。结果:与对照组相比,观察组分娩时间明显提前,早产率(67.01%)、剖宫产率(92.78%)以及产后出血发生率(38.14%)均明显升高,差异均有统计学意义(均P<0.05)。结论:妊娠期肝内胆汁淤积症孕妇合并乙型肝炎感染时免疫功能下降,妊娠结局较差,应早期做好隔离措施避免病毒传播,密切监测预防早产和产后出血的发生,保证母儿健康。
Objective: To investigate the effects of hepatitis B virus infection on the immune system of pregnant women with intrahepatic cholestasis of pregnancy (ICP) and pregnancy outcome analysis. Methods: A total of 267 pregnant women with intrahepatic cholestasis of pregnancy who came to the gynecology department from January 2009 to January 2014 were retrospectively analyzed. Among them, 97 cases were complicated with hepatitis B virus (HBV) infection, and there was no HBV infection 170 cases as control group. The immune function of pregnant women (IL-18, IL-12, TNF-α) and pregnancy outcomes were compared. Results: Compared with the control group, the delivery time of the observation group was significantly earlier, the rate of premature delivery (67.01%), cesarean section rate (92.78%) and postpartum hemorrhage rate (38.14%) were significantly increased, the differences were statistically significant (All P <0.05). Conclusion: Pregnant women with intrahepatic cholestasis of pregnancy have decreased immune function in hepatitis B infection and pregnancy outcomes are poor. Early isolation should be done to avoid the spread of virus, and the prevention and cure of preterm and postpartum hemorrhage should be closely monitored to ensure the health of both mother and child.