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低分子右旋糖酐(Dextran—40)临床广泛应用于缺血性中风及各种休克。近几年,该药临床应用引起的不良的反应屡有报道,并有过敏致死病例报告,现报道一例如下:患者,男性,66岁。因患冠心病、脑动脉硬化于1996年8月9日15:00收住院,给予10%葡萄糖加能量合剂静滴,16:40接低分子右旋糖酐500ml 加复方丹参10ml,输入约30ml,患者自诉心前区不适、胸闷、呼吸困难。检查:患者神清,呼吸困难明显,有喘鸣音,全身发绀,血压16/10kPa,心率120次/min。心电图示:窦性心动过速,一度房室传寻阻滞,心肌劳损、缺血。即给予供氧、皮下注射肾上腺素、更换输液、静注氨茶碱、地塞米松及钙剂、肌注非那根。继而患者大汗淋漓,血压下降至12/8kPa,应用升压药,30分钟后,患者逐渐神志不清,心音低,呼吸减慢,于17:30患者心跳停止,虽经持续胸
Low molecular dextran (Dextran-40) clinical widely used in ischemic stroke and shock. In recent years, the clinical application of the drug caused by adverse reactions frequently reported, and reports of allergic to lethal cases are reported as follows: patients, men, 66 years old. Due to coronary heart disease, cerebral arteriosclerosis at 15:00 on August 9, 1996 admitted to hospital, given 10% glucose plus energy mixture intravenous drip, 16:40 low molecular weight dextran 500ml plus compound Salvia 10ml, enter about 30ml, patient self-prosecution Precordial discomfort, chest tightness, difficulty breathing. Check: patients Shenqing, obvious breathing difficulties, wheezing, systemic cyanosis, blood pressure 16 / 10kPa, heart rate 120 beats / min. ECG shows: sinus tachycardia, once atrioventricular block, myocardial strain, ischemia. That is given oxygen, subcutaneous injection of epinephrine, replacement infusion, intravenous aminophylline, dexamethasone and calcium, intramuscular injection of non-root. Then the patient sweating, blood pressure dropped to 12 / 8kPa, the application of antihypertensive drugs, 30 minutes later, the patient gradually unconscious, low heart sound, slow breathing, at 17:30 patients with heartbeat stopped, despite sustained chest