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本文观察了由丙线照射所致胃粘膜萎缩后其适应性细胞保护作用的变化,及其与内源性PGE、PGI_2和 TXA_2的关系。结果表明,胃粘膜萎缩可明显地减弱由胃蛋白酶(150U 溶于0.1mol/L 盐酸)或20%酒精灌胃所引起的对牛磺胆酸所致的胃粘膜损伤的适应性细胞保护作用。在丙线照射后28 d 胃粘膜萎缩状态下,组织合成和释放 PGE 和 PGI_2的能力显著降低,而生成 TXA_2的能力则明显增强;给予上述两种弱刺激后15min,PGE 和 PGI_2含量的增加比无粘膜萎缩动物明显减少,PGI_2/TXA_2比值降低。预先5min 给予外源性 PGE_2,则可使丙线照射所抑制的适应性细胞保护作用重新恢复。这些结果说明,丙线照射可使大鼠胃粘膜的适应性细胞保护作用明显减弱,而胃组织 PGE 和 PGI_2合成和释放能力的降低以及 PGI_2/TXA_2比值下降,可能是产生这种现象的机制之一。
In this paper, we observed the change of adaptive cytoprotection after gastric mucosal atrophy caused by C-line irradiation and its relationship with endogenous PGE, PGI_2 and TXA_2. The results showed that gastric mucosal atrophy significantly attenuated the adaptive cytoprotective effect of taurocholic-induced gastric mucosal injury caused by pepsin (150U dissolved in 0.1mol / L hydrochloric acid) or gastric perfusion with 20% alcohol. The ability of tissue to synthesize and release PGE and PGI_2 was significantly decreased and the ability of TXA_2 production was significantly enhanced in gastric mucosal atrophy 28 days after C line irradiation. The increase of PGE and PGI_2 content 15 min after the two weak stimuli Mucosal atrophy animals significantly reduced, PGI_2 / TXA_2 ratio decreased. Preincubation of exogenous PGE 2 for 5 min may restore the adaptive cytoprotective effect inhibited by c-line irradiation. These results suggest that c-line irradiation significantly attenuates the adaptive cytoprotective effect on gastric mucosa in rats and that the decreased synthesis and release of PGE and PGI 2 in the gastric tissue and a decrease in the PGI 2 / TXA 2 ratio may be responsible for this phenomenon one.