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氯气中毒引起肺水肿的机制仍未彻底阐明,目前倾向于肺毛细血管通透性升高,本实验中我们采用麻醉剂戊巴比妥钠、α-肾上腺素能受体阻断剂酚妥拉明、β受体激动剂异丙肾上腺素及抗组织胺H_1受体制剂非那更等药物处理动物,观察它们在氯气中毒性肺水肿发生中的作用,初步探讨氯气中毒性肺水肿的发生机制,为临床防治氯气中毒性肺水肿提供实验依据。材料和方法:小自鼠90只,雌雄兼有,随机分为下列六组,每组15只。1.单纯氯气中毒组(单氯组),吸入氯气造成中毒。2.麻醉+氯气中毒组(麻氯组),事先腹腔注射戊巴比妥钠0.6mg/10g后吸入氯气。3.异丙肾上腺素+氯气中毒组(异氯组),事先腹腔注射异丙肾上腺索0.01mg/10g后吸入氯入。4.酚妥拉明+氯气中毒组(酚氯组),事先腹腔注射酚妥拉明
The mechanism of chlorine poisoning causing pulmonary edema has not yet been fully elucidated and presently there is an increased permeability of pulmonary capillaries. In this experiment we used anesthetic sodium pentobarbital, alpha-adrenergic receptor blocker phentolamine , Β receptor agonist isoproterenol and antihistamine H 1 receptor agents such as finasteride treatment of animals, to observe their role in the pathogenesis of chlorine poisoning pulmonary edema, to explore the mechanism of chlorine poisoning pulmonary edema, To provide experimental evidence for the clinical prevention and treatment of chlorine poisoning pulmonary edema. MATERIALS AND METHODS: Ninety mice, male and female, were randomly divided into the following six groups of 15. 1. Pure chlorine poisoning group (single chlorine group), inhalation of chlorine poisoning. 2. Anesthesia + chlorine poisoning group (chlorpromazine group), before intraperitoneal injection of pentobarbital sodium 0.6mg / 10g inhalation of chlorine. Isoproterenol + chlorine poisoning group (Isochromate group), before intraperitoneal injection of isoproterenol 0.01mg / 10g inhalation of chlorine into. 4. Phentolamine + chlorine poisoning group (phenolic chlorine group), prior ip injection of phentolamine