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近来发现在正常及恶性细胞的生长与构成中存在粘附系统。粘附系统通过细胞表面或细胞外基质分子促进细胞间或细胞-基质间的粘附。胎盘的合体滋养层是特殊的表皮,与母体血液直接接触。而母体的免疫系统细胞可能是通过粘附分子而直接与滋养层作用,但这方面的研究很少。已确定的滋养层上粘附分子有α_4、β_1整合素等。为进一步确定参与淋巴细胞与滋养细胞粘附的分子,作者利用有多种粘附分子表达的淋巴细胞系MOLT-4/克隆8与原代培养的人合体滋养细胞及一系列粘附分子的封闭单抗及细
Recently it has been found that there is an adhesion system in the growth and constitution of normal and malignant cells. The adhesion system promotes intercellular or cell-matrix adhesion through the cell surface or extracellular matrix molecules. Placenta trophoblast is a special epidermis, with direct contact with the maternal blood. The mother’s immune system cells may be directly through the adhesion molecules and trophoblast role, but little research in this area. Have been identified on the trophoblast adhesion molecules α_4, β_1 integrin and so on. In order to further identify the molecules involved in lymphocyte and trophoblast adhesion, the authors used a variety of adhesion molecule expression of lymphocyte cell line MOLT-4 / clone 8 and primary cultured human syncytiotrophoblast cells and a series of adhesion molecules closed Monoclonal antibody and fine