要适应发现新型感染药物的迫切需要,须建立可有效筛选庞大数量分子的筛选系统。对高毒性、药代动力学性质差或体内外相关性差的化合物缺乏有效剔除方法的旧筛选方法,已成为限制抗感染药物发现速度的瓶颈。Aussubel等对秀丽隐杆线虫(Caencrhabditis elegans)进行研究后发现,其可 To meet the urgent need to discover new infectious agents, screening systems that can effectively screen a large number of molecules should be established. Old screening methods that lack effective culling methods for compounds that are highly toxic, poorly pharmacokinetic, or poorly correlated in vivo have become a bottleneck in limiting the speed of anti-infective drug discovery. Aussubel et al. Studied Caencrhabditis elegans and found that