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在抗结核治疗中,以异烟肼,利福平和吡嗪酰胺为核心的化疗药物均具有肝细胞毒性,联合应用加重肝损的程度,且目前对药物性肝损的发病机制认识不清,影响因素也没有一致性的认同[1]。本研究以临床上1 662例住院肺结核病人为研究对象,探讨抗结核药物所致肝损的临床特征,旨在预防和干预肝损结局的发生,完善治疗方案。1对象与方法1.1研究对象采用统一设计的病例调查表,通过结核病管理信息系统数据库,查阅病例档案,以江苏
In the anti-TB treatment, chemotherapy drugs with isoniazid, rifampicin and pyrazinamide as the core all have hepatotoxicity, and the degree of liver damage is increased in combination. At present, the pathogenesis of drug-induced liver damage is not clear, There is no consistency of the influential factors [1]. In this study, clinical 1 662 cases of hospitalized tuberculosis patients for the study to explore the clinical features of anti-TB drug-induced liver damage, aimed at the prevention and intervention of the occurrence of hepatic damage and improve the treatment plan. 1 Subjects and methods 1.1 The research object using a unified design of the case questionnaire, through the database of tuberculosis management information system, access to case files to Jiangsu