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药物围产期毒性试验中,一般通过与阴性对照组和阳性对照组比较,检查亲代的分娩、哺乳以及子代生理发育和反射发育等指标,来判断药物对亲代和子代的影响。由于不同实验室人员和设施条件的不尽相同,判定的标准也会有所不一,致使试验结果分析会有偏差,包括源于主观因素的偏差。为了尽量减少判定误差,本文对围产期毒性试验中亲代和子代的指标标准化检测方法进行探讨,以使实验结果更加客观。
In the perinatal toxicity test of drugs, the effects of the drugs on the parents and offspring are generally judged by comparing with the negative control group and the positive control group, checking the indicators of childbirth, lactation and physiological development and reflex development of the offspring. Due to the different laboratory personnel and facilities conditions, the standard of judgment will be different, resulting in the analysis of test results will have deviations, including deviations from the subjective factors. In order to minimize the error of judgment, this paper discusses the standardization testing methods of parents and offspring in perinatal toxicity test to make the experimental results more objective.