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本文研究了抗心律失常新药Pirmenol对阵发性室上性心动过速(SVT)的治疗效果。 25例(年龄17～74岁)阵发性SVT病人,多数病人对常规抗心律失常药无效。17例自发性SVT病人,2分钟内静注本品50mg,无效者10分钟后可重复该剂量1次。治疗前开始每5分钟测血压和心电图间期一次,直至给药后30分钟。在诱发性SVT病人中,研究前停用所有抗心律失常药至少4个半减期,先于2分钟内静注本品50mg,随后用本品每分钟2.5 mg维持,药物或电刺激控制SVT后重复诱发试验,治疗前后行电生理检查。结果是11/17例(65%)自发性
This article investigates the therapeutic effect of Pirmenol, an anti-arrhythmic drug, on paroxysmal supraventricular tachycardia (SVT). 25 patients (17-74 years of age) with paroxysmal SVT patients, most patients with conventional antiarrhythmic drugs ineffective. 17 cases of spontaneous SVT patients, 2 minutes intravenous injection of this product 50mg, 10 minutes after the invalid can repeat the dose 1 times. Blood pressure and ECG interval were measured every 5 minutes before treatment until 30 minutes after dosing. In the induced SVT patients, all antiarrhythmic drugs were discontinued before the study for at least 4 and a half reductions, first intravenous injection of 50 mg of the product within 2 minutes and then 2.5 mg per minute of the product maintenance, drug or electrical stimulation control SVT After repeated induction test, electrophysiological examination before and after treatment. The result was 11/17 (65%) spontaneous