Deciphering structural and functional roles of disulfide bonds in decorsin

来源 :中国科学：化学英文版 | 被引量 : 0次 | 上传用户：a3470114

【摘要】

：

Decorsin,an antagonist of integrin glycoprotein IIb/IIIa,contains Arg-Gly-Asp(RGD)sequence and three disulfide bridges.The function of RGD sequence has already

【作者】

：

WU LingZhi LI Ying YANG Yang Q

【机构】

：

SchoolofGeographyandBiologicalInformation,NalionalLaboratoryofSolidStateMicrostructureandDepartmento

【出处】

：

中国科学：化学英文版

【发表日期】

：

2013年10期

【关键词】

：

二硫键键结构 RGD序列抗凝血活性破译生物活性插入突变受体拮抗剂 antihemostatic activity decorsin disulf

【基金项目】

：

This work was supported by the National Natural Science Foundation of China （91127026, 11074115 and 61101056）, and the Open Project of State Key Laboratory of Bioelectronics of Southeast University （2

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Decorsin,an antagonist of integrin glycoprotein IIb/IIIa,contains Arg-Gly-Asp(RGD)sequence and three disulfide bridges.The function of RGD sequence has already been well defined,but the roles of conserved disulfide bonds in antihemostatic proteins still r

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Deciphering structural and functional roles of disulfide bonds in decorsin

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