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目的：观察射频热疗联合与不联合胸腹腔灌注化疗，治疗恶性胸、腹腔积液的近期疗效、毒副反应及患者生存质量变化情况。方法将48例确诊为恶性肿瘤且伴恶性胸腹腔积液的患者随机分为：热疗联合灌注化疗组28例，单纯热疗组20例。采用中心静脉导管闭式引流排尽胸腹水后，热化疗组给予胸腹腔灌注化疗，然后进行射频热疗；单纯热疗组只给射频热疗。结果在控制恶性胸、腹腔积液和改善生存质量方面热化疗组75.0%，、64.2%，均优于单纯射频热疗组45.0%、35.0%，差异有统计学意义（<0.05）。结论射频热疗联合胸腹腔灌注化疗对晚期肿瘤合并恶性胸、腹腔积液的治疗效果优于单纯射频热疗。“,”Objective To observe radiofrequency hyperthermia in combination with pleural and peritoneal perfusion chemotherapy in treatment of malignant pleural ef usion, the short-term ef icacy, toxicity and survival quality change.Methods The patients were randomly divided into 48 cases were diagnosed as malignant tumor and with malignant pleural and peritoneal ef usion were:hyperthermia combined withchemotherapy group 28 cases, 20 cases of simple hyperthermia group. Using closed thoracic drainage with central venous catheters drained pleural ef usion and ascites afterthermochemotherapy group received pleural and peritoneal perfusion chemotherapy,then radio frequencyhyperthermia; hyperthermia grouponly to radiofrequency hyperthermia.Results In the control of malignant pleural ef usion and improve the life quality of heat chemotherapy group 75.0%,and 64.2%, are bet er than that of pure radiofrequency hyperthermia group 45.0% and 35.0%, the dif erence was statistical y significant ( <0.05).Conclusion Thoracic and abdominal cavity perfusion chemotherapycombined with radiofrequency hyperthermia on cancer patients with malignant pleural ef usion treatment ef ect is bet er than pure radiofrequency hyperthermia.