目的:研究子痫前期(PE)高危孕妇不同孕周开始应用小剂量阿司匹林联合低分子肝素预防孕妇发生子痫前期的临床研究.方法:选择在长治市妇幼保健院2020年1月-2020年12月期间接受治疗的330例子痫前期高危孕妇作为研究对象,依据孕期开始服用小剂量阿司匹林的时间其分为早期用药组、晚期用药组和对照组,针对三组孕妇的子痫前期发生率进行比对和分析.结果:早期用药组110例孕妇子痫前期发生率均低于晚期用药组及对照组,组间差异对比显示(P < 0.05),差异明显具备统计学意义.结论:子痫前期高危孕妇在孕早期开始服用小“,”Objective: To study the clinical study of low-dose aspirin combined with low-molecular-weight heparin in high-risk preeclampsia (PE) pregnant women at different gestational weeks to prevent preeclampsia in pregnant women. Methods: 330 cases of high-risk pregnant women with preeclampsia who were treated in Changzhi Maternity and Child Health Hospital from January 2020 to December 2020 were selected as the research objects. According to the time when they started taking low-dose aspirin during pregnancy, they were divided into early medication group and late medication Group and control group, compared and analyzed the incidence of preeclampsia in the three groups of pregnant women. Results: The incidence of preeclampsia in 110 pregnant women in the early medication group was lower than that in the late medication group and the control group. The difference between the groups showed (P<0.05), the difference was obviously statistically significant. Conclusion: Pre-eclampsia high-risk pregnant women start to take low-dose aspirin in the first trimester, stop aspirin at 34 weeks of pregnancy and switch to low-molecular-weight heparin subcutaneous injection, which can significantly reduce the incidence of preeclampsia and improve the pregnancy outcome, which has promotion and use value .