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应用微量细胞病变法检测血清中和抗体和流行病学方法观察肾综合征出血热(HFRS)Ⅱ型灭活疫苗在HFRS高发疫区人群加强免疫后的血清学和免疫效果.结果:加强免疫前血清抗体阳性率为18.5%,加强接种后14天抗体阳性率达到1OO%,GMT分别为3.2和17.05;加强免疫后一年接种组无一病例发生,而未接种组发病12例,发病率为101.2/10万,疫苗保护率100%.
Serum neutralizing antibody was detected by the method of micro-cytopathic effect and the epidemiological method was used to observe the serological and immune effects of type II HFRS inactivated vaccine in HFRS high-risk area.Results: Before immunization The positive rate of serum antibody was 18.5%. The antibody positive rate reached 100% at 14 days after inoculation and the GMT was 3.2 and 17.05 respectively. None of the inoculation group in one year after booster immunization occurred, while in non-vaccinated group, the incidence was 101.2 / 100000, vaccine protection rate of 100%.