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目的:观察糖尿病性白内障(diabetic cataract,DC)患者血清和房水中丙二醛(MDA)与超氧化物歧化酶(superoxide dismutase,SOD)的变化,探讨氧化应激与DC的关系。方法:分别测定68例DC患者(DC组)、62例单纯糖尿病患者(D组)、60例单纯白内障患者(C组)和同期50例非糖尿病非白内障眼科手术者(NS组)血清和房水中MDA与SOD的水平。结果:与NS组比较,D组和C组患者血清和房水中MDA水平升高,SOD水平下降(均P<0.05),但D组和C组之间差异无统计学意义;与D组或C组比较,DC组MDA升高,SOD下降更明显(均P<0.05)。Pearson相关分析显示,MDA与SOD呈负相关(r=-0.835,P<0.05);Logistic回归分析显示,MDA和SOD是DC的影响因素(均P<0.05)。结论:糖尿病性白内障患者血清和房水中MDA水平升高,SOD水平下降,氧化应激可能参与了DC的发生发展。
Objective: To investigate the changes of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum and aqueous humor of patients with diabetic cataract (DC) and to explore the relationship between oxidative stress and DC. Methods: The serum levels of 68 patients with DC (DC group), 62 patients with simple diabetes mellitus (Group D), 60 patients with simple cataract (Group C) and 50 patients with non-diabetic non-cataract ophthalmic surgery (NS group) Water MDA and SOD levels. Results: Compared with NS group, MDA level in serum and aqueous humor of D group and C group were increased and SOD level was decreased (all P <0.05), but there was no significant difference between D group and C group; Compared with group C, MDA in DC group increased and SOD decreased more significantly (all P <0.05). Pearson correlation analysis showed that there was a negative correlation between MDA and SOD (r = -0.835, P <0.05). Logistic regression analysis showed that MDA and SOD were the influential factors of DC (all P <0.05). CONCLUSIONS: The levels of MDA and the level of SOD in serum and aqueous humor of patients with diabetic cataract are increased, and the oxidative stress may be involved in the occurrence and development of DC.