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目的:从肠管运动功能的角度,探讨中药“十八反”中海藻与甘草配伍禁忌的机制。方法:观察海藻与甘草单煎液、合并液和合煎液对大鼠离体回肠收缩活动的影响,及其单煎液与合煎液对小鼠在体小肠推进功能的影响,分别记录离体回肠收缩张力和在体小肠推进距离,并计算其回肠张力差及小肠推进率。结果:海藻单煎液能浓度依赖性增加大鼠离体回肠的收缩张力,0.1-2mg生药/mL时有显著性差异(P<0.01);与甘草合用后其升高回肠收缩张力的作用显著减弱(P<0.05)。海藻低、中、高剂量(0.78、1.56、3.12g/kg)能显著增加小鼠小肠推进率(P<0.05),而海藻-甘草(1∶1)合煎液对小肠推进率无显著影响。结论:海藻能促进大鼠离体回肠和小鼠小肠运动,当与甘草合用后其生物效应受到明显抑制。甘草可能通过对肠管运动的抑制,产生了抑制海藻“润下”、“利水”的功效,这为海藻与甘草配伍禁忌理论提供了一定实验证据。
Objective: To explore the mechanism of taboo compatibility between seaweed and licorice root in traditional Chinese medicine “Eighteen Antibodies” from the perspective of intestine motor function. Methods: The effects of seaweed and licorice decoction, combined solution and combined decoction on the contractile activity of rat ileum in vitro were studied. The effects of decoction of single decoction and co-decoction on the function of small intestine in mice were recorded. Ileal contraction tension and in vivo small intestine propulsion distance, and calculate the ileal hypotension and intestinal propulsion rate. Results: The decoction of seaweed decoction could increase the contraction tension of ileum in vitro in a concentration-dependent manner, with a significant difference (P <0.01) at 0.1-2mg crude drug / mL; Weakened (P <0.05). Low, medium and high doses of seaweed (0.78,1.56,3.12g / kg) could significantly promote the small intestine (P <0.05), while seaweed-licorice (1: 1) combined decoction had no significant effect on the small intestine . Conclusion: Seaweed can promote intestinal motility in isolated ileum and mice, and its biological effects are obviously inhibited when combined with licorice. Glycyrrhiza may inhibit the intestinal movement, resulting in the inhibition of seaweed, “Run under,” “water” effect, which for the algae and licorice compatibility taboo theory provides some experimental evidence.