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［ 目的］ 探讨表皮生长因子和ｒａｓＰ２１ 在胃癌组织中的表达特点和临床病理意义．［ 方法］ 免疫组织化学链霉亲和素过氧化物酶法检测３５ 例胃癌和５ 例慢性萎缩性胃炎中表皮生长因子和ｒａｓＰ２１ 的表达及其协同表达规率．［ 结果］ 表皮生长因子和ｒａｓＰ２１ 均在胃癌癌旁不典型增生和肠上皮化生组织中表达率最高，其次为胃癌组织，与正常胃粘膜区比较有显著性差异，二者协同阳性表达率随着分化程度的降低而升高．在２ 例伴中度不典型增生的慢性萎缩性胃炎标本中二者表达协同阳性．［ 结论］ 表皮生长因子和ｒａｓＰ２１ 的过表达发生在胃癌发展过程的早期阶段，对胃癌的早期诊断有重要意义．
[Objective] To investigate the expression characteristics and clinicopathological significance of epidermal growth factor and rasP21 in gastric cancer. [Methods] Immunohistochemical streptavidinperoxidase method was used to detect the expression of epidermal growth factor and rasP21 in 35 cases of gastric cancer and 5 cases of chronic atrophic gastritis. [Results] The expression rates of epidermal growth factor and rasP21 in gastric atypical hyperplasia and intestinal metaplasia were the highest, followed by gastric cancer, and there was significant difference from normal gastric mucosa. The degree of differentiation has decreased and increased. In the 2 cases of chronic atrophic gastritis with moderate atypical hyperplasia, the two expressed synergistic positive. [Conclusion] Overexpression of epidermal growth factor and rasP21 occurs in the early stages of the development of gastric cancer and is of great significance for the early diagnosis of gastric cancer.