γδT淋巴细胞在免疫反应中的作用还不完全清楚,但已有实验表明其对炎症损伤的发展有影响。本文通过建立李斯特菌感染小鼠模型,比较了不同亚型γδT细胞对宿主抗感染的影响。已知,Vγ基因的表型与T细胞对特定抗原的反应能力相关。因此,通过尾静脉注射纯化的抗-Vγ1、抗-Vγ4及抗-Cδ单克隆抗体以清除特定亚型的γδT细胞(所有单克隆抗体来自仓鼠的IgG)。对照组小 The role of γδT lymphocytes in the immune response is not fully understood, but experiments have shown that it has an impact on the development of inflammatory lesions. In this paper, we established a mouse model of Listeria infection and compared the effect of different subtypes of γδT cells on host anti-infective. It is known that the phenotype of the V [gamma] gene correlates with the ability of T cells to respond to a particular antigen. Therefore, purified anti-Vγ1, anti-Vγ4 and anti-δδ monoclonal antibodies were injected via the tail vein to clear the γδ T cells of a particular subtype (all monoclonal antibodies from hamsters). Small control group