【摘 要】
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Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanismsunderlying the effects of
【机 构】
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Department of Neurosurgery,Tianjin Medical University General Hospital“,”Tianjin Neurological Instit
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Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanismsunderlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunctionand remote symptomatic epilepsy. In this study, we examined the relationship between traumatic brain injury-induced neuronal loss andsubsequent hippocampal regional excitability. We used hydraulic percussion to generate a rat model of traumatic brain injury. At 7 daysafter injury, the mean modified neurological severity score was 9.5, suggesting that the neurological function of the rats was remarkablyimpaired. Electrophysiology and immunocytochemical staining revealed increases in the slope of excitatory postsynaptic potentials andlong-term depression (indicating weakened long-term inhibition), and the numbers of cholecystokinin and parvalbumin immunoreactivecells were clearly reduced in the rat hippocampal dentate gyrus. These results indicate that inteuronal loss and changes in excitabilityoccurred in the hippocampal dentate gyrus. Thus, traumatic brain injury-induced loss of inteurons appears to be associated with reducedlong-term depression in the hippocampal dentate gyrus.
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