本文报道两株抗丙二醛修饰的低密度脂蛋白单克隆抗体（ＨＭＬ１、ＨＭＬ２），两者均有较高的抗体效价．抗体类型为ＩｇＧ２ａ。单抗相加实验表明，ＨＭＬ１和ＮＭＬ２识别同一抗原位点。竞争性ＢＡ－ＥＬＩＳＡ实验显示：ＨＭＬ１能够识别丙二醛修饰的低密度脂蛋白、丙二醛清蛋白、丙二醛聚赖氨酸。但与天然低密度脂蛋白无交叉反应。推测ＨＭＬ１抗原位卢、与低密度脂蛋白在修饰过程中雨二醇和载脂蛋白Ｂ上的赖氨酸残基形成的共价结合物相关。 Two anti-malondialdehyde-modified low-density lipoprotein monoclonal antibodies (HML1, HML2) were reported in this paper, both of which have high antibody titer. The antibody type is IgG2a. Mab resistance experiments show that HML1 and NML2 recognize the same antigenic site. Competitive BA-ELISA experiments showed that: HML1 can recognize malondialdehyde-modified low density lipoprotein, malondialdehyde albumin, malondialdehyde polylysine. But no cross-reaction with natural LDL. The HML1 epitope was speculated to be associated with a covalent conjugate of low-density lipoproteins formed by the lysine residues on the diol and apolipoprotein B during the modification.