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为探讨血管内皮生长因子(VEGF)在上皮性卵巢癌中的表达及其与腹水形成的关系,采用免疫组化LSAB法,检测20例良性肿瘤及39例恶性卵巢上皮性肿瘤细胞中VEGF的表达,并分析其表达与临床病理指标的关系,结果表明,VEGF在良性和恶性卵巢肿瘤中的阳性表达率分别为10.0%(2/20)和84.6%(33/39),两组间阳性表达率及表达强度差异均有非常显著意义(P<0.001)。VEGF的表达与肿瘤细胞分化程度及腹腔内播散无明显相关性(P>0.05),与临床分期有一定的相关性,与腹水形成显著相关(P<0.05)。结论:VEGF在卵巢癌中的阳性表达率高于良性肿瘤,与其腹水形成相关。
To investigate the expression of vascular endothelial growth factor (VEGF) in epithelial ovarian cancer and its relationship with the formation of ascites, immunohistochemistry LSAB method was used to detect the expression of VEGF in 20 cases of benign tumor and 39 cases of malignant ovarian epithelial tumor , And analyzed its relationship with clinicopathological parameters. The results showed that the positive rates of VEGF in benign and malignant ovarian tumors were 10.0% (2/20) and 84.6% (33/39), respectively There was significant difference in the rate and expression intensity (P <0.001). There was no significant correlation between the expression of VEGF and the degree of tumor cell differentiation and intraperitoneal dissemination (P> 0.05). The expression of VEGF was correlated with the clinical stage and with the formation of ascites (P <0.05). Conclusion: The positive rate of VEGF expression in ovarian cancer is higher than that in benign tumor, which is related to the formation of ascites.