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在细胞色素P-450单加氧酶模拟体系中,金属卟啉已被用作较好的模型化合物。位阻型金属卟啉对烷烃的羟基化和烯烃的环氧化显示出特殊的选择性和稳定性。所谓位阻型卟啉就是在四苯基卟啉的苯基邻位上引入适当的取代基团,起到双面保护作用,以防止卟啉环被氧化降解。对于卟啉环上的苯基在间位带有两个
In the cytochrome P-450 monooxygenase simulation system, metalloporphyrins have been used as better model compounds. Sterically hindered metalloporphyrins show exceptional selectivity and stability for the alkylation of alkanes and the epoxidation of olefins. The so-called steric porphyrin is introduced in the phenyl ortho-tetraphenylporphyrin appropriate substituent groups, play a double-sided protection, in order to prevent oxidation of porphyrin ring degradation. The phenyl group on the porphyrin ring has two in the meta position