真菌感染引起的疾病在临床上呈现较快的上升趋势,在国际上引起了广泛的重视。新型隐球酵母是主要病原真菌之一。过去十余年,对其致病的分子生物学研究有了较大的进展。重要致病因子(virulence factors)的合成调控及致病过程中信号传导途径等研究进展较快,这些都可能成为治疗甚至预防该真菌的焦点。本文在简要介绍致病因子的基础上,详细综述了分子生物学研究的进展情况。 Fungal infections caused by the disease showed a rapid clinical upward trend in the world has aroused widespread attention. Cryptococcus neoformans is one of the major pathogenic fungi. Over the past ten years, its pathogenic molecular biology has made great progress. The progress of synthesis and regulation of important virulence factors and signal transduction pathways in the pathogenic process are fast, and these may become the focus of treatment or even prevention of the fungus. Based on the brief introduction of virulence factors, this article reviewed the progress of molecular biology in detail.