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AIM:Chronic liver diseases,such as fibrosis or cirrhosis,are more common in men than in women.This genderdifference may be related to the effects of sex hormones onthe liver.The aim of the present work was to investigatethe effects of estrogen on CCL_4-induced fibrosis of the liverin rats.METHODS:Liver fibrosis was induced in male,female andovariectomized rats by CCL4 administration.All the groupswere treated with estradiol(1 mg/kg)twice weekly.Andtamoxifen was given to male fibrosis model.At the end of 8weeks,all the rats were killed to study serum indicators andthe livers.RESULTS:Estradiol treatment reduced aspartateaminotransferase(AST),alanine aminotransferase(ALT),hyaluronic acid(HA)and type Ⅳ collagen(CIV)in sera,suppressed hepatic collagen content,decreased the areas ofhepatic stellate cells(HSC)positive for a-smooth muscle actin(α-SMA),and lowered the synthesis of hepatic type Ⅰ collagensignificantly in both sexes and ovariectomy fibrotic rats inducedby CCL_4administration.Whereas,tamoxifen had the oppositeeffect.The fibrotic response of the female liver to CCL_4treatment was significantly weaker than that of male liver.CONCLUSION: Estradiol reduces CCL_4-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be one reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis.
AIM: Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender ofference may be related to the effects of sex hormones onthe liver. The aim of the present work was to investigate the effects of estrogen on CCL_4- induced fibrosis of the liver in rats. METHODS: Liver fibrosis was induced in male, female andovariectomized rats by CCL4 administration. All of the groups were treated with estradiol (1 mg / kg) twice weekly. Attamoxifen was given to male fibrosis model. At the end of of 8weeks, all the rats were killed to study serum indicators and the livers. RESULTS: Estradiol treatment reduced aspartate aminotransferase (AST), alanine aminotransferase (ALT), hyaluronic acid (HA) and type IV collagen decreased the areas of hepatic stellate cells (HSC) positive for a-smooth muscle actin (α-SMA), and lowered the synthesis of hepatic type I collagensignificantly in both sexes and ovariectomy fibrotic rats inducedby CCL_4administration .Whereas, tamoxifen had the opposite effect of the fibrotic response of the female liver to CCL_4 treatment was significantly weaker than that of male liver. CONCLUSION: Estradiol reduces CCL_4-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be a reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis.