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目的 观察化疗后头颈部鳞癌颈淋巴结改变,探讨化疗对颈淋巴结包膜外转移的影响。方法 对11例头颈部鳞癌颈淋巴结临床触诊N2～N3病人,术前应用一周期化疗,CDDP,MTX PYM然后施以根治术,并将颈清术淋巴结标本做连续切片,光镜观察,结果 在11例病人12侧颈清术标本中,颈淋巴结226枚,病理检查阳性淋巴结81枚,有包膜外转移淋巴结19枚,增生性淋巴结58枚。讨论 化疗后,头颈部鳞癌病人仍有淋巴结包膜外转移,根治性颈清除术疗效满意。
Objective To observe the changes of cervical lymph nodes in squamous cell carcinoma of the head and neck after chemotherapy and to investigate the effect of chemotherapy on the out-migration of cervical lymph nodes. Methods 11 cases of head and neck squamous cell carcinoma of the neck were clinically palpated in N2~N3 patients. One-cycle chemotherapy, CDDP, and MTX PYM were applied before radical surgery. Lymph node specimens from neck dissection were consecutively sectioned. Light microscopy was performed. RESULTS: Of the 12 patients who underwent neck dissection in 11 patients, 226 were cervical lymph nodes, 81 were pathological positive lymph nodes, 19 were extracapsular metastatic lymph nodes, and 58 were hyperplastic lymph nodes. Discussion After chemotherapy, head and neck squamous cell carcinoma patients still have metastatic lymph nodes, and radical neck dissection is satisfactory.