【摘 要】
：
Methotrexate (MTX) is a common folate antagonist and it blocks the dihydrofolate reductase,thereby causing tetrahydrofolate formation disorder.Tetrahydrofolate
【机 构】
：
Physical Science and Technical College, Shenyang Normal University, Shenyang 110034, China“,”State K
论文部分内容阅读
Methotrexate (MTX) is a common folate antagonist and it blocks the dihydrofolate reductase,thereby causing tetrahydrofolate formation disorder.Tetrahydrofolate is the active folate form and its related metabolic products are required for DNA synthesis and DNA methylation modification.The effects of MTX have been demonstrated by DNA methylation aberrations,DNA damage,and DNA synthesis obstruction,causing cell replication disorder and apoptosis [1,2].Since MTX passes through blood-brain,blood-testis,and blood-ocular barriers,high-dose MTX is commonly used to treat malignancies in clinic (the high dose generally is the total dosage of MTX ＞1 g once or single dose ＞20 mg/kg) [3].The main defect of MTX treatment is its insufficienttumor targeting because MTX kills cancer cells and at the same time also destroys the normal cells [2].Additionally,MTX has also been reported to reduce the oocyte quality [4].
其他文献
Plant hormones are essential elements that control a great number of cellular processes that occur during plant growth.Abscisic acid (ABA) is a plant hormone kn
一、垦稻3号的育成及其特点垦稻3号是本所1973年用外地引入的矮脚南特×无芒早沙粳的稳定后代作母本,用大雪作父本杂交育成的。母本是含有我国著名矮秆早籼“矮脚南特”血缘
本文从套期保值操作中基差风险的产生原因入手,研究了基差风险最小的套期保值策略,为企业、个人在期货市场上操作套期保值时提供了较好的分析价格风险、降低投资组合的系统性
医院不仅是患者接受诊疗获得康复的场所,同时也是病原菌传播和易感人群集中的地方;医院感染是指住院患者在医院内获得的感染。感染控制过程中的任何疏漏都可能引起医院感染。
RNA has multiple functions in nature, including informa- tional transfer (mRNA) Ill, adaptor function (tRNAs) [2], guide functions (snRNAs, snoRNAs) [3,4]cataly
目的探讨围产儿死亡的原因,进一步降低围产儿病死率。方法对2005-2009年平谷区围产儿死亡病例的一般情况、产前检查情况、死亡原因进行分析。结果 2005-2009年全区围产儿病死
男人营养素为国家批准的正规国食健字产品,GMP认证企业,纯中药提取,从根本上提高男人精气神,增强人体免疫力,促进二次发育,治养结合,从而能够治疗男性两大方面困扰,一、肾虚:
Cofilin2,an actin-binding protein,is expressed in many eukaryotic cells.It binds to and depolymerizes the actin filaments,and its activity is regulated by phosp
Acute coronary syndrome (ACS) is associated with sudden,reduced blood flow to the heart and usually correlated with coronary thrombosis [1].Therefore,platelets
目的 了解西山区居民弓形虫感染情况.方法 对西山区居民677份血清进行弓形虫抗体水平监测.结果 居民总体感染率3.40%;男女感染率差异无统计学意义(P>0.05);职业间以务农居民