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目的探讨硫酸镁与酚妥拉明联合硝苯地平治疗妊娠高血压综合征的临床疗效。方法选取120例2015年1月至2016年12月期间在庄河市妇幼保健院产科就诊的妊娠高血压综合征患者为研究对象进行研究,以患者入院时间奇偶数为依据将其分为两组,对照组60例患者采用单一用药治疗,即给予患者硫酸镁静脉滴注治疗;观察组60例患者采用联合用药治疗,即给予患者硫酸镁、酚妥拉明和硝苯地平联合用药治疗,对比两组患者的治疗效果。结果采用联合治疗的观察组患者临床治疗总有效率明显高于对照组;治疗前比较两组患者的平均动脉压(MAP)、血细胞比容(Hct)、24 h蛋白定量(PRO-U)、脐动脉血流速度峰谷比(S/D)均差异无统计学意义(均P>0.05),而治疗后观察组患者上述指标均明显优于对照组(均P<0.05);且两组比较不良反应发生率存在明显差异(P<0.05)。结论采用硫酸镁、酚妥拉明和硝苯地平联合用药的方式对妊娠高血压综合征患者进行治疗效果显著,可达到平稳降压的效果,还能减少围产期不良反应发生。
Objective To investigate the clinical efficacy of magnesium sulfate and phentolamine combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome. Methods A total of 120 patients with pregnancy induced hypertension syndrome treated in obstetrics department of Zhuanghe MCH from January 2015 to December 2016 were enrolled in this study. The patients were divided into two groups , The control group of 60 patients treated with a single medication, that is given intravenous infusion of magnesium sulfate in patients; observation group of 60 patients treated with combination therapy, that is given to patients with magnesium sulfate, phentolamine and nifedipine combination therapy, compared with two Group of patients treatment effect. Results The total effective rate of clinical treatment in the observation group was significantly higher than that of the control group. The mean arterial pressure (MAP), hematocrit (Hct), protein content (PRO-U) There was no significant difference in the peak-to-peak ratio (S / D) of umbilical artery velocity (all P> 0.05), but the above indexes in the observation group were significantly better than those in the control group (all P <0.05) The incidence of adverse reactions was significantly different (P <0.05). Conclusion The combination of magnesium sulfate, phentolamine and nifedipine in the treatment of patients with pregnancy induced hypertension syndrome is significant, can achieve a stable antihypertensive effect, but also reduce the incidence of perinatal adverse reactions.