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目的 在建立C6 Wistar胶质瘤大鼠模型的基础上 ,研究1 2 5IUdR介导俄歇电子释放对大鼠C6胶质瘤DNA靶点放疗后的大鼠生存分析。方法 建立C6 Wistar胶质瘤大鼠模型后 ,将Wistar大鼠分为实验组 (2 0只 )、对照组 (2 0只 )和空白组 (10只 ) 3组 ,前两组再分为 5日处死和生存分析两个亚组。实验组在肿瘤增殖高峰期于肿瘤接种原位分次注入1 2 5IUdR ,0 2mCi 10 μl 次 ;对照组同法注入等摩尔浓度的1 2 7IUdR ,5 6 μM 10 μl 次 ;空白组同法洲入等量生理盐水 ,10 μl 次。了解1 2 5IUdR和1 2 7IUdR治疗后 3组动物的生存情况。结果 在 5 0天的观察期内 ,实验组有 2只生存下来 ,实验组中期生存时间比空白组和对照组延长了 1倍多 (P <0 0 5 )。
OBJECTIVE: To establish a rat model of C6 Wistar glioma and to investigate the survival of rats after radiotherapy with 125IUdR-mediated Auger electron emission in rat C6 glioma. Methods Wistar rats were divided into experimental group (20 rats), control group (20 rats) and blank group (10 rats). The first two groups were divided into 5 groups Day sacrifice and survival analysis of two subgroups. In the experimental group, 125 IUdR and 0 2 mCi 10 μl injections were performed in situ at the peak of tumor proliferation. The control group was injected with equimolar concentrations of 127 IUdR and 56 μM 10 μl times. In the blank group, Into the same amount of saline, 10 l times. To understand the survival of 3 groups of animals after 125IUdR and 127IUdR treatment. Results During the observation period of 50 days, two of the experimental group survived, and the median survival time of the experimental group was more than double that of the blank group and the control group (P <0.05).