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目的:观察行体外受精-胚胎移植妇女血清的C-反应蛋白浓度变化。方法:收集2004年1月～2005年2月在本中心接受体外受精-胚胎移植治疗的223例妇女236个周期资料,分别检测启动日、HCG日、取卵日及胚胎移植日(ET日)的血清C-反应蛋白浓度。结果:C-反应蛋白由启动日的(2.07±2.30)mg/L升至ET日的(4.82±8.67)mg/L(P<0.01)。在启动日、HCG日、取卵日,非妊娠妇女组平均血清C-反应蛋白浓度分别为(2.27±2.56)mg/L、(1.59±0.71)mg/L、(2.75±4.38)mg/L,高于妊娠组的(1.75±2.33)mg/L、(1.50±0.79)mg/L、(1.82±1.70)mg/L,P<0.05;ET日非妊娠妇女组平均CRP浓度(4.74±9.45)mg/L,低于妊娠组(4.96±8.23)mg/L,P<0.05。结论:在IVF治疗周期,经过控制性超排卵,血清C-反应蛋白浓度明显升高,提示控制性超排卵潜在有全身的炎症反应,一定程度的C-反应蛋白水平升高有助于IVF妇女成功妊娠。
Objective: To observe the changes of serum C-reactive protein in women undergoing in vitro fertilization and embryo transfer. Methods: Totally 236 cycle data of 223 women who underwent IVF-ET from January 2004 to February 2005 were collected. The data of start-up day, HCG day, ovulation day and embryo transfer day (ET day) Serum C-reactive protein concentration. Results: The C-reactive protein increased from (2.07 ± 2.30) mg / L on the starting day to (4.82 ± 8.67) mg / L on ET day (P <0.01). The serum C-reactive protein concentrations at the start-up day, HCG day, ovulation day and nonpregnant women were (2.27 ± 2.56) mg / L, (1.59 ± 0.71) mg / L and (2.75 ± 4.38) mg / L (1.75 ± 2.33) mg / L, (1.50 ± 0.79) mg / L, (1.82 ± 1.70) mg / L, respectively, P <0.05). The average CRP levels in non-pregnant women on ET were 4.74 ± 9.45 ) mg / L, lower than that of pregnancy group (4.96 ± 8.23) mg / L, P <0.05. CONCLUSIONS: With controlled ovarian hyperstimulation (IVF), serum C-reactive protein levels are significantly elevated during the IVF treatment cycle, suggesting a possible systemic inflammatory response to controlled ovarian hypersynchrony. Elevated C-reactive protein levels may be of benefit to IVF women Successful pregnancy.