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目的探讨初诊2型糖尿病患者检测尿视黄醇结合蛋白(RBP)与尿微量白蛋白/尿肌酐比值(ACR)的临床意义。方法选择本院内分泌病区新诊断的2型糖尿病患者110例为实验组,留取晨尿5 m L,早上空腹采静脉血6 m L。尿液标本分别用免疫比浊法检测尿RBP和尿微量白蛋白(MALB),用酶法检测尿肌酐(UCr);血清标本用酶法检测尿素(Urea),肌酐(SCr);检测均在全自动生化分析仪上进行。根据检测结果计算尿微量白蛋白与尿肌酐比值(ACR),然后分别计算尿RBP和ACR的阳性率。结果与对照组比较,实验组尿RBP,ACR差异有统计学意义(P<0.05),并且尿RBP,ACR的阳性率差异也有统计学意义(P<0.05)。结论部分初诊2型糖尿病患者已有早期肾损伤的发生,检测尿视黄醇结合蛋白(RBP)与尿微量白蛋白/尿肌酐比值(ACR)对早期糖尿病肾病的诊断和预防糖尿病肾病并发症的发生有重要临床意义。
Objective To investigate the clinical significance of detecting urine retinol binding protein (RBP) and urinary albumin / urinary creatinine ratio (ACR) in newly diagnosed type 2 diabetic patients. Methods One hundred and ten patients with newly diagnosed type 2 diabetes mellitus in our hospital were selected as the experimental group. The morning urine was collected for 5 m L and the fasting veins for 6 m L. morning. The urinary samples were respectively tested for urinary RBP and urine microalbumin (MALB) by immunoturbidimetry and urinary creatinine (UCr) by enzymatic method. Urea and creatinine (SCr) Automatic biochemical analyzer. According to the test results, the urinary albumin to urinary creatinine ratio (ACR) was calculated, and the positive rates of urinary RBP and ACR were calculated respectively. Results Compared with the control group, the urinary RBP and ACR in the experimental group were significantly different (P <0.05), and the positive rates of urinary RBP and ACR were also significantly different (P <0.05). Conclusions Some patients with newly diagnosed type 2 diabetes mellitus have had early renal injury. The detection of urinary retinol binding protein (RBP) and urinary albumin / urinary creatinine ratio (ACR) in the diagnosis of early diabetic nephropathy and the prevention of complications of diabetic nephropathy There is an important clinical significance.