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目的：探究不同剂量的利血平抑郁模型效果。方法：将36只试验大鼠随机分为研究组（分成3剂量组，每组9只）与对照组（9只），其中研究组3组分别腹腔注射2、4、6mg/kg利血平，对照组腹腔则注射相同体积溶剂，两组大鼠在注射1小时后利用开场实验对大鼠自发活动改变进行评价。结果：研究组大鼠注射利血平后可引发大鼠的抑郁样行为，其中4mg/kg组与2mg/kg组差异性显著（P＜0．05），与6mg/kg组则无显著性差异（P＞0．05）；研究组大鼠抑郁行为（1～3天）会随着利血平增加而降低，若继续增加剂量抑郁行为不会增加而呈现平台样变化。结论：利血平可以引发大鼠抑郁样行为，其引发抑郁样行为的合适剂量为4mg/kg。“,”Objective :To explore the effect of different dose of reserpine model of depression .M ethods :36 experimental rats were ran-domly divided into study group (divided into 3 groups ,9 in each group) and control group (9 rats) ,the study group of 3 group were intraper-itoneal injection of 2 ,4 ,6mg/kg of reserpine ,control group were intraperitoneal injection the same volumesolvent ,two groups of rats at 1 h post injection the opening experiment to evaluate changes in locomotor activity in rats .Results :the study group rats were injected with reser-pine induced depression like behavior in rats ,thedifference between 4mg/kg group and 2mg/kg group significantly (P0 .05);thedepressive behaviors of rats (1~3 days) will decrease with the increase of reser-pine ,if continue to increase in depression behavior dose not increases platform like changes .Conclusion :reserpine can cause the rat depres-sion like behaviors ,the appropriate dose of depressive like behavior for 4mg/kg .