妊娠期肝内胆汁郁积症的家族性发病特点和遗传倾向国内外文献都有记载,但未见详细报告,作者曾报道1例姐妹妊娠期复发性黄疸症(中华妇产科杂志1981;2:87)。本文报告母亲和姐妹两代三人发病,以引起同道们对本病遗传病因的探讨。例1.王×,30岁,住院号49481。孕8个月时除面部耳后外全身瘙痒,奇痒难眠,上腹不适,食欲正常,能照常工作,无畏寒发热。检查:体温37℃,巩膜微黄,周身满布搔痒痕,肝脾不大。宫底脐上2指,头位,胎心好。化验:黄疸指数(Ⅱ)20单位,谷丙转氨酶(SGPT)140单位,血清胆红质(SB)1.4mg％,其他肝功能均正常,尿三胆(一),HBsAg(一).于1980年12月13日足月娩出一女婴,体重2300g,产后出血50ml。产后三天SGPT116单位,SB0.4mg％,一周后痒止,二周后黄疸消退,肝功能正常。产后四 Familial incidence of intrahepatic cholestasis of pregnancy characteristics and genetic predisposition literature have been documented, but no detailed report, the authors have reported 1 case of recurrent jaundice during pregnancy (Chinese Journal of Obstetrics and Gynecology 1981; 2: 87). This article reports the incidence of three mothers and sisters two generations to cause fellow on the genetic causes of this disease. Example 1. Wang ×, 30 years old, hospital number 49481. 8 months pregnant when the face except the ear after the whole body itching, itching, sleepy, abdominal discomfort, normal appetite, can work as usual, no chills fever. Check: body temperature 37 ℃, scleral yellowish, whole body covered with itch marks, liver and spleen not. Palace umbilical 2 means, head position, good fetal heart. Assay: 20 units of jaundice index (II), 140 units of alanine aminotransferase (SGPT) and 1.4 mg of serum bilirubin (SB), all other liver functions were normal, December 13, 2010 full-term delivery of a baby girl, weighing 2300g, postpartum hemorrhage 50ml. Three days postpartum SGPT116 unit, SB0.4mg%, itch after a week, jaundice two weeks later subsided, normal liver function. Four postpartum