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目的:研究血尿酸水平与缺血性卒中的相关性。方法:选择缺血性卒中患者(病例组)100例和健康体检者(对照组)100例,分别测定空腹血尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),并对病例组进行颈部动脉超声检查、NIHSS评分、BI指数计算。比较两组尿酸水平及病例组不同血尿酸水平下UA、TC、TG、LDL-C、HDL-C的指标变化及NIHSS评分、BI指数、颈部血管斑块形成率的差别。结果:病例组和对照组空腹血尿酸升高的例数,分别为46例和17例,分别占46%和17%;血尿酸平均浓度分别为485.96±76.03(μmoL/L)和343.12±61.46(μmoL/L),差异有统计学意义。病例组尿酸结果明显高于对照组,两组比较有显著性差异(P<0.01);病例组UA、TC、TG、LDL-C、HDL-C水平较正常对照组差异有显著意义(P<0.05)。对病例组血尿酸水平,颈部血管超声结果、NIHSS评分、BI指数进行分析。病例组患者血尿酸水平与病情及预后有平行关系,即血尿酸水平高,颈部血管斑块形成率高,病情重,预后差。结论:高尿酸血症(HUA)是缺血性卒中重要的危险因素,是防治缺血性卒中的综合因素之一。
Objective: To study the correlation between serum uric acid level and ischemic stroke. Methods: One hundred patients with ischemic stroke (case group) and 100 healthy volunteers (control group) were enrolled in this study. Fasting serum uric acid (UA), total cholesterol (TC), triglyceride (TG), low density lipoprotein LDL-C and HDL-C. The neck artery ultrasound, NIHSS score and BI index of the cases were calculated. The levels of UA, TC, TG, LDL-C and HDL-C were compared between the two groups of uric acid levels and cases of different uric acid levels and NIHSS score, BI index, the difference of cervical vascular plaque formation rate. Results: The number of fasting serum uric acid increased in case group and control group were 46 cases and 17 cases, accounting for 46% and 17% respectively. The average serum uric acid concentrations were 485.96 ± 76.03 (μmoL / L) and 343.12 ± 61.46 (μmoL / L), the difference was statistically significant. The results of uric acid in case group were significantly higher than those in control group (P <0.01). The levels of UA, TC, TG, LDL-C and HDL-C in case group were significantly higher than those in control group (P < 0.05). Serum uric acid levels, ultrasound findings of neck vessels, NIHSS score and BI index were analyzed. Serum uric acid levels in patients with a parallel relationship with the disease and prognosis, that is, high blood uric acid level, high incidence of cervical vascular plaque, severe illness, poor prognosis. Conclusion: Hyperuricemia (HUA) is an important risk factor for ischemic stroke and is one of the comprehensive factors in the prevention and treatment of ischemic stroke.