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目的探讨孕妇发砷含量与胎儿先天性心脏病(CHD)的关系。方法采用病例对照研究,收集福建省妇幼保健院相关病例61例,对照组61例按年龄及孕周11配对。检测分析研究对象的发砷含量,进行问卷调查和分析。结果发砷含量(中位数)病例组孕妇(0.098μg/g)高于对照组(0.066μg/g);病例组胎儿心脏畸形简单型孕妇发砷含量(0.0892μg/g)低于复杂型(0.1227μg/g);复杂型中合并2种、3种和4种心脏畸形孕妇的发砷含量分别为0.1177、0.1212和0.1429μg/g;多因素分析发现,孕妇发砷含量、孕妇为家庭主厨、孕期接触化学制剂是CHD的危险因素;孕前食用乳制品为CHD的保护因素。结论胎儿CHD发生与孕妇发砷含量水平有关,发砷含量越高胎儿CHD风险越大。在孕前保健时对发砷含量较高的妇女进行干预,有助于降低胎儿CHD的发病风险。
Objective To investigate the relationship between arsenic content in pregnant women and fetal congenital heart disease (CHD). Methods A case-control study was conducted in 61 maternal and child hospital-related cases in Fujian Province, and 61 cases in the control group were matched according to age and gestational age. Detection and analysis of the research object of arsenic content, questionnaires and analysis. Results Arsenic content (median) pregnant women (0.098μg / g) was higher than that of the control group (0.066μg / g). The arsenic content (0.0892μg / g) (0.1227μg / g). The contents of arsenic in pregnant women complicated by 2, 3 and 4 cardiac malformations were 0.1177, 0.1212 and 0.1429μg / g, respectively. Multivariate analysis showed that pregnant women developed arsenic levels and pregnant women were family Chef, chemical exposure during pregnancy is a risk factor for CHD; pre-pregnancy dairy products for the protection of CHD. Conclusion The incidence of fetal CHD is related to the level of arsenic in pregnant women. The higher the level of arsenic, the higher the risk of fetal CHD. Interventions for pregnant women with high levels of arsenic during prenatal care can help reduce the risk of fetal CHD.