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目的探讨肝细胞生长因子(HGF)在喉鳞状细胞癌发生中的作用及其与喉鳞状细胞癌临床病理特征及淋巴结转移的关系。方法应用ELISA技术检测了36例喉鳞状细胞癌患者术前、术后及25例健康青年男性血浆HGF水平。结果喉鳞状细胞癌患者血浆HGF水平较正常人明显升高,术后患者血浆HGF水平明显下降。血浆HGF水平与肿瘤大小、血管有无癌细胞浸润、腋淋巴结有无转移以及TNM分期有关,而与确诊时年龄无关。结论HGF在人喉鳞状细胞癌的发生中具有重要作用,能够促进喉鳞状细胞癌的发生和发展,可作为喉鳞状细胞癌独立的预后因子。
Objective To investigate the role of hepatocyte growth factor (HGF) in the pathogenesis of laryngeal squamous cell carcinoma and its relationship with the clinicopathological features and lymph node metastasis of laryngeal squamous cell carcinoma. Methods The plasma levels of HGF in 36 patients with laryngeal squamous cell carcinoma before and after operation and in 25 healthy young men were detected by ELISA. Results The plasma levels of HGF in patients with laryngeal squamous cell carcinoma were significantly higher than those in normal controls and the levels of plasma HGF in patients with laryngeal squamous cell carcinoma were significantly decreased. Plasma HGF level and tumor size, vascular cancer cell infiltration, axillary lymph node metastasis and TNM staging, but not with the age of diagnosis. Conclusions HGF plays an important role in the occurrence of human laryngeal squamous cell carcinoma, which can promote the occurrence and development of laryngeal squamous cell carcinoma and may be an independent prognostic factor for laryngeal squamous cell carcinoma.