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目的评价阿奇霉素注射液治疗急性呼吸道感染、泌尿道感染及皮肤软组织感染的安全性和有效性。方法阿奇霉素注射液静脉滴注,每次250mg,每日1次,首次剂量加倍,疗程5d;对照药红霉素每日1g~1.5g,分1~2次静脉滴注,疗程7~14d。结果阿奇霉素注射液与红霉素随机对照治疗呼吸道、泌尿道及皮肤软组织感染134例,其中试验组69例,对照组65例。试验组与对照组的临床有效率(停药后1周)分别为94.2%与75.5%,细菌清除率分别91.9%与83.3%;不良反应发生率分别为8.45%与24.62%,以上结果经统计学处理有显著性差异(P<0.05)。结论阿奇霉素注射液静脉点滴,每次250mg,每日1次,首次剂量加倍,对敏感致病菌引起的轻、中度呼吸道感染,泌尿道感染及皮肤软组织感染均有很好临床疗效和细菌学疗效,不良反应发生率低。
Objective To evaluate the safety and efficacy of azithromycin injection in the treatment of acute respiratory infections, urinary tract infections and skin and soft tissue infections. Methods Azithromycin injection intravenously, each 250mg, 1 day, the first dose doubled, treatment 5d; control erythromycin daily 1g ~ 1.5g, divided into 1 or 2 times intravenously, treatment 7 ~ 14d. Results Azithromycin injection and erythromycin randomized treatment of respiratory tract, urinary tract and skin and soft tissue infections in 134 cases, of which 69 cases of test group, control group of 65 cases. The clinical effective rate (94.2% and 75.5% respectively) in the experimental group and the control group were 91.9% and 83.3% respectively, and the rates of adverse reactions were 8.45% and 24.62% respectively. The above results were statistically analyzed There was significant difference between the two groups (P <0.05). Conclusion Azithromycin injection intravenously, each 250mg, once daily, the first dose doubled, sensitive to pathogens caused by mild to moderate respiratory tract infections, urinary tract infections and skin and soft tissue infections have a good clinical efficacy and bacteriology Curative effect, the incidence of adverse reactions is low.