Eastern Tianshan, a cardinal part of Northern Xinjiang compound continental crustoblock, is located in the east of Tianshan Diwa region. By analysis of regional geological and geophysical data, and by using crustobody theory and researching methods, this region can be divided into three sectors of different crustal structure. During Proterozoic to Eopaleozoic, the spreading and closing of Northern Tianshan Sea, on the foundation of disparate continental basements of each sectors, the transversal heterogeneity of tectonic movement and evolution resulted in the diversity of crustal structure and material formations. The metallogenic evolution indicated that different geotectonic evolution periods had not only different characteristics of mineralization commodity and mineral deposit types, but also the progressive mineralization feature. In Neopaleozoic, the closing of Northern Tianshan Sea from north to south and the difference of transmeridional tectonic deformation and magmation formed in the movement constituted the different metallogenic environment in shallow crust. Furthermore, it brought on the diverse Cu-Au-polymetal mineral deposit types and metallogenetic epoch from north to south and from west to east.