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目的探讨结节性甲状腺肿乳头状增生良恶性病变特点。方法选择90例结节性甲状腺肿病变,经常规HE染色,光镜检查,并使用显微测微尺测量乳头状增生良恶性病变细胞核的大小。结果恶性乳头状增生:乳头分枝多、密集,核深染,可见泡状核、核沟、核内假包涵体、砂粒体等特征;良性乳头状增生:乳头分枝少,乳头细长或短小,被覆细胞与正常甲状腺上皮相似。良恶性病变结构、细胞核形态之间存在差异。原诊断为甲状腺乳头状瘤10例,复查后符合结节性甲状腺肿囊性变乳头状增生。结论结节性甲状腺肿发病过程可诱发癌变,良恶性乳头状增生的鉴别诊断对判断患者预后有一定参考意义。
Objective To investigate the characteristics of benign and malignant lesions of nodular goiter papillary hyperplasia. Methods Totally 90 cases of nodular goiter were selected and examined by HE staining and light microscopy. The size of nucleus in benign and malignant papillary hyperplasia was measured by microscopic micrometer. Results Malignant papillary hyperplasia: many papillary branches, dense, deep-stained nuclei, visible bubbly nucleus, nuclear ditch, intranuclear false inclusions, sand bodies and other characteristics; benign papillary hyperplasia: less nipple branches, slender nipples or Short, covered cells are similar to normal thyroid epithelium. There are differences between benign and malignant lesions and nuclear morphology. The original diagnosis of thyroid papilloma in 10 cases, after review consistent with nodular goiter cystic papillary hyperplasia. Conclusion The pathological process of nodular goiter can induce carcinogenesis. The differential diagnosis of benign and malignant papillary hyperplasia has certain reference value in judging the prognosis of patients.