酸中毒后室性心律失常仿真研究

来源 :生物化学与生物物理进展 | 被引量 : 0次 | 上传用户:snower2010
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
本文旨在分析酸中毒对心脏电生理活动的影响,探讨其诱发室性心律失常的机制.首先建立了具有pH和钙/钙调素依赖蛋白激酶Ⅱ(calcium/calmodulin dependent protein kinaseⅡ,Ca MKⅡ)调控作用的人体心室酸中毒计算模型,然后模拟了酸中毒过程中细胞和组织电活动的变化,并定量分析了心电图的改变情况.实验结果表明:在酸中毒期间,细胞动作电位时程的缩短和复极离散度的降低导致心电图QT间期缩短、T波幅值和宽度减小.同时,细胞静息电位的抬高和最大去极化速率的降低也促进了组织电兴奋的缓慢传导和传导阻滞.另外,酸中毒后的初期,肌浆网钙超载促进钙释放增多,导致细胞产生延迟后除极(delayed afterdepolarization,DADs),使心电图上表现为室性早搏.而缓慢传导、传导阻滞和室性早搏有利于折返波的产生,进而发展为室速.因此,酸中毒后细胞的触发活动是诱发室性心律失常的主要原因之一. The purpose of this article is to analyze the effect of acidosis on cardiac electrophysiological activity and to explore the mechanism of ventricular arrhythmia induced by acidosis.Firstly, the mechanism of pH and calcium / calmodulin dependent protein kinase Ⅱ (Ca MKⅡ) And then simulate the change of cell and tissue electrical activity during acidosis and quantitatively analyze the changes of ECG.Experimental results show that during the period of acidosis, the shortening of cell action potential duration And the decrease of repolarization dispersion lead to shortening of QT interval and decrease of amplitude and width of T wave.At the same time, elevation of cell resting potential and decrease of maximum depolarization rate also promote the slow conduction of tissue electrical excitement and Conduction retardation.In addition, early after acidosis, calcium overload of sarcoplasmic reticulum increases the release of calcium, leading to delayed delayed dedelaction (DADs) of cells, which leads to premature ventricular contractions on ECG.The slow conduction and conduction Blocking and premature ventricular premature beats favor the generation of reentry waves, which in turn develop into ventricular tachycardia. Thus, the triggering activity of cells after acidosis is the induction of ventricular arrhythmias One of the main reasons.
其他文献
目的探讨慢性再生障碍性贫血与易感染状态相关性,为临床治疗提供有效治疗手段。方法选取2010年4月-2015年4月于医院收治的慢性再生障碍性贫血患者60例,对所有患者填写统一制
摘要:由于社会经济的迅速发展,不少人在物质财富中失去方向,贪污舞弊,滥用职权。会计职业道德存在着诸多失范的现象,究其原因,主要是会计从业人员职业道德的失范所致。遵守会计基本职业道德是对会计人员树立良好的职业品质,严谨的工作作风,以及努力提高工作效率的基本要求与规范。  关键词:会计职业道德建设    一、会计职业道德基本内涵  所谓会计人员职业道德,就是在会计职业实践中用善良、良心、义务等形式来调