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研究了硒和维生素Ｅ（ＶＥ）对大鼠血浆和心肌血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）水平及ＴＸＡ２／ＰＧＩ２比值的影响。发现饲低硒、ＶＥ的克山病病区粮组动物在谷胱甘肽过氧化物酶降低和自由基净含量、脂质过氧化物（ＬＰＯ）浓度增高的同时，ＴＸＡ２水平增高、ＰＧＩ２水平降低、ＴＸＡ２／ＰＧＩ２比值增高；加硒或／和ＶＥ对纠正上述变化有相似而又不尽相用的效果，而以联合补充效果量佳。本研究结果提示硒和ＶＥ缺乏通过影响花生四烯酸代谢参与克山病缺血缺氧性心肌坏死的发生发展，其机制可能与二者缺乏，抗氧化能力降低，生成过量自由基和ＬＰＯ，抑制了ＰＧＩ２合成酶的作用并促进ＴＸＡ２形成有关。
The effects of selenium and vitamin E (VE) on TXA2, PGI2 and TXA2 / PGI2 ratio in plasma and myocardium of rats were studied. It was found that in the Keshan disease group with low selenium and VE, the levels of TXA2, TXA2 and PGI2 levels increased with the decrease of glutathione peroxidase and the increase of the concentration of free radicals and the concentration of lipid peroxide (LPO) Reduce, TXA2 / PGI2 ratio increased; plus selenium or / and VE to correct the above changes are similar but not all the same effect, and combined with the amount of good results. The results of this study suggest that selenium and VE deficiency through participation of arachidonic acid metabolism in Keshan disease hypoxic-ischemic myocardial necrosis development, its mechanism may be the lack of both, reduced antioxidant capacity, generate excess free radicals and LPO, Inhibits the action of PGI2 synthase and promotes the formation of TXA2.