【摘 要】
：
Nonalcoholic fatty liver disease (NAFLD) exhibits sexual dimorphism, with men being more exposed than women to the risk of simple steatosis, nonalcoholic steato
【机 构】
：
Operating Unit of Metabolic Syndrome,Azienda Ospedaliero-Universitaria di Modena,Ospedale Civile di
论文部分内容阅读
Nonalcoholic fatty liver disease (NAFLD) exhibits sexual dimorphism, with men being more exposed than women to the risk of simple steatosis, nonalcoholic steatohepatitis fibrosis, and hepatocellular carcinoma (HCC), while the protection conferred to women seemingly disappears with aging and reproductive senescence (i.e., menopause). HCC, the most common primary liver cancer, which carries an ominous prognosis, may result from various genetic and non-genetic risk factors. NAFLD is now projected to become the most common cause of HCC. HCC also exhibits a definite sexual dimorphism in as much as it has a worldwide high male-to-female ratio. In this review article, we focus on sex differences in the epidemiological features of HCC. Moreover, we discuss sex differences in the clinical outcome and molecular pathobiology of NAFLD-HCC. By highlighting the research gaps to be filled, the aim of this review is to prompt future research of sex differences in HCC and facilitate developing personalized cancer prevention strategies, detection, and treatments to achieve better patient outcomes in NAFLD-HCC, considering sex differences in HCC pathobiology.
其他文献
胰十二指肠切除术(pancreaticoduodenectomy, PD)是治疗胆总管下段,胰头及壶腹部周围良恶性肿瘤的主要手术方法.手术过程复杂,涉及脏器多,并且手术创伤大,并发症发生率高.早
Since the Milan Criteria (MC) were adopted in many countries as the allocation policy criteria for patients with hepatocellular carcinoma to be transplanted, ma
This review focuses on emerging abbreviated magnetic resonance imaging (AMRI) surveillance of patients with chronic liver disease for hepatocellular carcinoma (
Hepatocellular carcinoma (HCC) has one of highest mortalities globally amongst cancers, but has limited therapeutic options once in the advanced stage. Hepatiti
Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells. Dendritic cells (DCs) have the capac
1病例患者,女,56岁,2019年6月28日到当地私人诊所注射“美容针除皱”,3d后感上唇无力,进食食物卡塞,喝汤饮水侧漏,一周后感搏动性头晕昏沉,为持续性。随后出现左眼睑下垂,无晨清暮重,无视物重影,无咀嚼困难,MRI检查发现双侧基底节区少量腔隙性脑梗塞灶,双侧侧脑室旁白质区、双侧半卵圆区中心多发缺血性损害灶;7月13日以左眼睑下垂查因:药物不良反应(肉毒素?)重症肌无力待排,入住我院神经内科进一步诊治。
The epidemiology of nonalcoholic fatty liver disease goes hand-in-hand with the obesity pandemic. The pathogenesis of fatty liver has shifted from an hepatocent
目的:观察经皮耳穴迷走神经刺激(taVNS)对功能性消化不良(FD)大鼠心率变异性(HRV)及自主神经功能的影响,探讨taVNS治疗FD的机制。方法:将SD大鼠随机分为正常组8只,造模组26只。采用碘乙酰胺灌胃法复制FD大鼠模型。将FD大鼠随机分为模型组、taVNS组、taVNS假刺激组、足三里组,每组6只。taVNS组大鼠给予耳穴迷走神经电刺激,taVNS假刺激组仅将电极线固定在耳穴不予电刺激,足三里组予电刺激“足三里”,各组每次均干预30 min, 1次/d,连续14 d。采用颈斜方肌肌电(EMG
With the development of second-generation contrast agents and advancement in contrast harmonic imaging, contrast-enhanced ultrasonography (CEUS) now has the cap
近年来,随着我国交通、建筑行业的飞速发展,车祸伤、高处坠落伤日益增多,我科胸腰椎骨折患者的收治也呈上升趋势。胸腰椎骨折患者术后伤口的拆线时间、窦道口炎以及伤口引流管的脱出直接影响患者的生活质量与康复进程。本文选取了2018年1月-2019年4月我科收治的行胸腰椎骨折后方入路手术的胸腰椎骨折患者66例,探讨束腹带加压在预防胸腰椎骨折患者术后并发症的效果观察,现报告如下。