论文部分内容阅读
目的采用Meta分析系统评价淋巴毒素α(lymphotoxin-α,LTA)基因A252G、C804A多态性与心肌梗死(my-ocardial infarction,MI)的关系。方法检索PubMed和CNKI数据库(2002-2008年)中所有有关上述两种多态与MI相关性的随机病例对照研究,并用Revman4.2软件进行统计分析。结果共纳入9篇符合条件的文献,累计A252G多态研究例数:MI病例15809例、对照9566例;C804A多态研究人数:MI病例16356例、对照9966例。数据合并结果显示,病例与对照之间GG252/(GA252+AA252)基因型的比值比(oddsratio,OR)为1.14,95%CI:0.94-1.38(P=0.19);AA804/(AG804+GG804)基因型的OR=1.06,95%CI:0.85-1.30(P=0.62)。另外,按东西方人群分组后的分析结果也与上述结果一致(P>0.05)。结论LTA基因GG252和AA804基因型不是MI的风险因子。受纳入文献数量的限制,本Meta分析结果尚有待更多高质量的大样本研究予以进一步证实。
Objective To evaluate the relationship between A252G, C804A polymorphisms of lymphotoxin-α (LTA) gene and myocardial infarction (MI) by Meta-analysis. Methods Randomized case-control study of PubMed and CNKI database (2002-2008) in relation to the above two polymorphisms and MI was searched and analyzed by Revman 4.2 software. Results A total of 9 eligible articles were included in the study. The cumulative number of A252G polymorphism cases was 15,809 cases in MI and 9566 cases in control. The number of C804A polymorphism cases was 16,356 cases in MI and 9,966 cases in control group. The data showed that odds ratio (OR) of GG252 / (GA252 + AA252) genotypes between cases and controls was 1.14, 95% CI 0.94-1.38 (P = 0.19), AA804 / (AG804 + GG804) OR for genotype = 1.06, 95% CI: 0.85-1.30 (P = 0.62). In addition, the analysis results grouped by East-West population are also consistent with the above results (P> 0.05). Conclusion The genotypes of LTA GG252 and AA804 are not risk factors of MI. Due to the limited number of included articles, the results of this meta-analysis have yet to be further substantiated by more high-quality large sample studies.