吲哚里西丁类生物碱的结构复杂多变,手性中心多,具有良好的抗癌、抗病毒等生物活性,但由于其毒性等原因很少直接用于临床.高效、高选择性地合成吲哚里西丁类生物碱衍生物及其类似物具有重要的意义.其合成目前主要是通过贵金属的不对称催化氢化来实现,很少通过催化不对称串联反应合成的报道来完成.近年来,清华大学化学系王梅祥课题组致力于开发稳定叔烯酰胺的反应及其在天然产物和生物活性分子合成中的应用.最近,他们成功 Indolibidine alkaloids are complex and changeable in structure, and have many chiral centers, which have good biological activities such as anticancer and antiviral activity, but they are seldom directly used in clinic due to their toxicity and the like. The synthesis of indolibidine alkaloid derivatives and their analogs is of great significance.The synthesis is currently mainly achieved by the asymmetric catalytic hydrogenation of precious metals and is rarely reported by catalyzing the synthesis of asymmetric tandem reactions , Wang Meixiang, Department of Chemistry, Tsinghua University, is devoted to the development of stable tertiary amides and their application in the synthesis of natural products and bioactive molecules. Recently, they successfully