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目的:观察血培养阳性脓毒症检出菌的变迁规律,探讨与其预后相关的因素。方法:总结2010年至2013年我院呼吸内科血培养阳性脓毒症136株检出菌及相关指标,并将其分为两组:一组为治愈及好转组,二组为未愈及死亡组,使用统计软件进行单因素分析,筛选出可能与脓毒症预后相关的因素。结果:主要以凝固酶阴性葡萄球菌(CNS)为首,其次为大肠埃希氏菌,发现耐亚胺培南大肠埃希菌株一例,其耐药率为2.9%;两组间进行比较,对年龄、性别、基础疾病包括心血管病、脑血管病后遗症、糖尿病、恶性肿瘤在内、住院前是否应用抗生素、发热程度、是否存在肺部感染及低白蛋白血症进行单因素分析,肺部感染情况P<0.05,有统计学意义,可认为其与脓毒症的预后相关,其余指标P均>0.05,尚不能认为其与脓毒症预后相关。结论:革兰阳性球菌是血培养阳性脓毒症的主要致病菌;肺部感染情况与脓毒症的预后相关。
Objective: To observe the changes of bacteria detected in blood culture positive sepsis and explore the factors related to its prognosis. Methods: From 2010 to 2013, 136 strains of bacteria positive for blood culture positive sepsis in our hospital were collected and divided into two groups: one was cured and improved, the other two were unhealed and died Groups, using statistical software univariate analysis, screening out factors that may be related to the prognosis of sepsis. Results: The most common strains were Escherichia coli, mainly coagulase-negative staphylococci (CNS). One case of imipenem-resistant Escherichia coli was found, with a resistance rate of 2.9%. The comparison of age, , Gender, basic diseases including cardiovascular disease, cerebrovascular sequelae, diabetes, malignancy, whether to use antibiotics before hospitalization, the degree of fever, the presence of pulmonary infection and hypoalbuminemia for univariate analysis of lung infections The situation P <0.05, statistically significant, it can be considered associated with the prognosis of sepsis, the remaining indicators P> 0.05, can not be considered associated with the prognosis of sepsis. CONCLUSIONS: Gram-positive cocci are the major causative agents of blood-culture-positive sepsis; lung infections are associated with the prognosis of sepsis.