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目的：探讨复方地芬诺酯复制功能性便秘家兔模型的可行性。方法模型组采用复方地芬诺酯混悬液经口灌胃15 d，空白组予以相应量的蒸馏水灌胃。观察家兔首粒黑便时间、24 h粪便颗粒数以及24 h粪便质量，以判断模型的复制情况。结果与空白对照组家兔比较，模型组家兔的首粒黑便排出时间明显延长，粪便重量减轻，粪便颗粒数减少，并表现出不同程度的精神状态的改变。结论复方地芬诺酯灌胃可用于制作家兔功能性便秘模型，但在造模过程中要尽量避免各种不利因素的影响。“,”Objective To explore the feasibility on the functional constipation rabbit model duplicated by compound diphenoxylate tablet. Methods Mixed suspension of compound diphenoxylate tablet was used to conduct gavage through the mouth for 15 days in the model group. At the same time , the control group was given the correspounding amount of distilled water lavage.The discharging time of the first grain of black feces,fecal weight and grains in 24 hours were observed to judge the replication of the model.Results Compared with the control group,the discharging time of the first grain of black feces of the model group was prolonged obviously.The fecal weight and grains were reduced,and showed different degrees of mental status change.Conclusion The gavage of compound diphenoxylate tablet can be used to make functional constipation rabbit model.However,we should avoid all kinds of unfavorable factors during the experiment.