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目的为指导临床合理用药提供依据,提高疗效。方法常规细菌培养,细菌的鉴定和药敏采用美国BD公司phoenix-100全自动细菌鉴定及药敏分析系统。结果2005年6月-2008年6月在某医院烧伤科伤口分泌物中检出病原株301株,其中G-杆菌184株,G+球菌109株,真菌8株。G-杆菌对氨苄西林的耐药率最高(83.9%),其次为头孢噻吩(73.3%)和头孢唑啉(72.8%),耐药率最低的是亚胺培南(2.1%),其次是呋喃妥因(37.5%)和阿米卡星(44%),G+葡萄球菌除万古霉素外,对其他18种抗生素的耐药率,MRSA均高于MSSA。肠球菌对青霉素和红霉素耐药情况严重。结论此医院烧伤病房创面分泌物细菌耐药率普遍较高,应加强耐药性监测。
Objective To provide a basis for clinical rational use of drugs to improve efficacy. Methods Conventional bacterial culture, bacterial identification and drug sensitivity using the United States BD phoenix-100 automatic bacterial identification and drug sensitivity analysis system. Results From June 2005 to June 2008, 301 strains of pathogens were detected in the wound secretions of a hospital’s burn department, including 184 strains of G-bacteria, 109 strains of G-bacteria and 8 strains of fungi. The antibacterial rate of ampicillin in G-bacilli was the highest (83.9%), followed by cefalotin (73.3%) and cefazolin (72.8%), and the lowest rates were imipenem (2.1%), followed by Nifuvastatin (37.5%) and amikacin (44%), Staphylococcus aureus in addition to vancomycin, the other 18 kinds of antibiotic resistance rates, MRSA were higher than MSSA. Enterococci resistant to penicillin and erythromycin in serious condition. Conclusion The rate of bacterial resistance to wound secretions in this hospital burn ward is generally high, and drug resistance monitoring should be strengthened.