富血小板血纤蛋白(PRF)是由法国科学家Choukroun于2000年提出的新一代血小板浓缩物。PRF制备简便,无任何人工或生物制剂,降低了感染性疾病传播的风险;其血纤蛋白的立体网状三分子结构柔韧而有弹性,可将细胞因子等包埋嵌合于其孔隙中缓慢释放,为迁徙细胞提供支架;富含的诸多与组织愈合和骨修复相关的细胞因子,可促进组织的愈合;其免疫细胞释放的炎症因子,具有调节炎症反应和抗感染的作用。本文就PRF的生物学特性、PRF促进组织修复的机制、PRF的临床应用等研究进展作一综述。 Platelet-rich fibrin (PRF) is a new generation of platelet concentrates proposed by the French scientist Choukroun in 2000. The preparation of PRF is simple, without any artificial or biological agents, reducing the risk of transmission of infectious diseases; its three-dimensional network of fibrin network structure flexibility and flexibility, can be embedded in the pores and other cytokines embedded in the slow Release, provide the support for migratory cells; rich in many of the tissue healing and bone repair-related cytokines, can promote tissue healing; immune cells release of inflammatory cytokines, with the regulation of inflammatory reactions and anti-infection effect. This article reviews the biological characteristics of PRF, PRF mechanism of promoting tissue repair, clinical application of PRF and so on.